IL-21 Receptor: Regulation of Immune and Inflammatory Signals

Target Name: Interleukin 21 receptor complex

NCBI ID: P5684

Interleukin 21 receptor complex

Other Name(s): IL-21 receptor | Novel interleukin receptor | IL-21R | CD360

IL-21 Receptor: Regulation of Immune and Inflammatory Signals

Interleukin 21 (IL-21) receptor complex is a protein complex that plays a crucial role in the regulation of immune and inflammatory responses. The IL-21 receptor is a cytoplasmic protein that is expressed in a variety of tissues, including immune cells, endothelial cells, and epithelial cells. It is a member of the IL-21 receptor subfamily, which includes several other proteins that are involved in the regulation of immune responses, including IL-1, IL-6, and IL-23.

The IL-21 receptor is involved in the regulation of several different signaling pathways, including the T cell signaling pathway and the immune tolerance pathway. The T cell signaling pathway is involved in the regulation of T cell proliferation, differentiation, and selection, and is critical for the development and maintenance of an effective immune response. The immune tolerance pathway is involved in the regulation of the immune response, including the regulation of T cell responses against self-reactive antigens.

The IL-21 receptor is also involved in the regulation of inflammation, including the regulation of pro-inflammatory and anti-inflammatory responses. The IL-21 receptor is able to regulate the production of pro-inflammatory cytokines, such as TNF-alpha, IL-18, and IL-19, as well as the regulation of anti-inflammatory cytokines, such as IL-10.

The IL-21 receptor is a potential drug target for the treatment of several different diseases, including autoimmune diseases, cancer, and obesity. The overproduction of pro-inflammatory cytokines, such as TNF-alpha, IL-18, and IL-19, is a hallmark feature of many autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. The IL-21 receptor is thought to be involved in the regulation of the production of these pro-inflammatory cytokines, and therefore may be a useful target for the treatment of these diseases.

The IL-21 receptor is also a potential biomarker for several different diseases, including cancer and obesity. The production of pro-inflammatory cytokines, such as TNF-alpha, IL-18, and IL-19, is often increased in cancer cells, and the IL-21 receptor is thought to be involved in the regulation of this process. Therefore, the IL-21 receptor may be a useful biomarker for the detection and diagnosis of cancer.

The IL-21 receptor is also involved in the regulation of obesity, a disease that is characterized by an excess of body weight and a range of health problems, including cardiovascular disease, diabetes, and certain types of cancer. The IL-21 receptor is thought to be involved in the regulation of the appetite and energy homeostasis, which are important factors in the regulation of obesity.

In conclusion, the IL-21 receptor is a protein complex that plays a crucial role in the regulation of immune and inflammatory responses. It is involved in the regulation of several different signaling pathways, including the T cell signaling pathway and the immune tolerance pathway. The IL-21 receptor is also involved in the regulation of inflammation, including the regulation of pro-inflammatory and anti-inflammatory responses. The IL-21 receptor is a potential drug target for the treatment of several different diseases, including autoimmune diseases, cancer, and obesity. Further research is needed to fully understand the role of the IL-21 receptor in these processes and to develop effective treatments.

Protein Name: Interleukin 21 Receptor Complex

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